SARS-CoV-2 Omicron sublineage BA.2 replaces BA.1.1: Genomic surveillance in Japan from September 2021 to March 2022 - 03/07/22
Doi : 10.1016/j.jinf.2022.04.040
Yosuke Hirotsu a, ⁎ 
, Makoto Maejima b , Masahiro Shibusawa b , Yume Natori b , Yuki Nagakubo b, c , Kazuhiro Hosaka b , Hitomi Sueki b , Hitoshi Mochizuki a, d, e , Toshiharu Tsutsui f , Yumiko Kakizaki f , Yoshihiro Miyashita f , Masao Omata e, g
, Makoto Maejima b , Masahiro Shibusawa b , Yume Natori b , Yuki Nagakubo b, c , Kazuhiro Hosaka b , Hitomi Sueki b , Hitoshi Mochizuki a, d, e , Toshiharu Tsutsui f , Yumiko Kakizaki f , Yoshihiro Miyashita f , Masao Omata e, g a Genome Analysis Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan
b Division of Microbiology in Clinical Laboratory, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan
c Division of Genetics and Clinical Laboratory, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan
d Central Clinical Laboratory, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan
e Department of Gastroenterology, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan
f Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan
g The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
⁎Corresponding author at: Genome Analysis Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan.Genome Analysis CenterYamanashi Central Hospital1-1-1 FujimiKofuYamanashiJapan
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• | The more infectious Omicron sublineage BA.2 replaced sublineage BA.1.1. |
• | Sublineage BA.2 infection produced a higher viral load compared with BA.1.1 infection |
• | High viral loads were observed for both BA.1.1 and BA.2 across all age groups. |
Keywords : SARS-CoV-2, Variant of concern, Omicron, BA.1, BA.2
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© 2022
Publié par Elsevier Masson SAS.
Vol 85 - N° 2
P. 174-211 - août 2022 Retour au numéro
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