Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients - 03/07/22
Doi : 10.1016/j.jinf.2022.05.033
Samreen Ijaz a, ⁎ 
, Steve Dicks a, b, Keerthana Jegatheesan a, b, Eleanor Parker c, Ksenia Katsanovskaja c, Elen Vink d, Myra O. McClure c, J. Shute a, Joshua Hope e, Nicola Cook e, Peter Cherepanov c, e, Lance Turtle f, g, William A. Paxton f, h, Georgios Pollakis f, h, Antonia Ho d, Peter J.M. Openshaw i, J. Kenneth Baillie j, Malcolm G. Semple f, k, Richard S. Tedder c
, Steve Dicks a, b, Keerthana Jegatheesan a, b, Eleanor Parker c, Ksenia Katsanovskaja c, Elen Vink d, Myra O. McClure c, J. Shute a, Joshua Hope e, Nicola Cook e, Peter Cherepanov c, e, Lance Turtle f, g, William A. Paxton f, h, Georgios Pollakis f, h, Antonia Ho d, Peter J.M. Openshaw i, J. Kenneth Baillie j, Malcolm G. Semple f, k, Richard S. Tedder cfor ISARIC4C Investigators1
ISARIC4C Investigators listed in supplemental material and at https://isaric4c.net/about/authors/.
a Blood Borne Virus Unit, Reference Department, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK
b NHS Blood and Transplant, London, UK
c Department of Infectious Disease, Imperial College London, London, UK
d Medical Research Council, University of Glasgow Centre for Virus Research, Glasgow, UK
e Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK
f Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK
g Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK
h NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK
i National Heart & Lung Institute, Imperial College, London, UK
j Roslin Institute, University of Edinburgh, Edinburgh, UK
k Department of Respiratory Medicine, Alder Hey Children's Hospital, Liverpool, UK
⁎Corresponding author.
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Highlights |
• | Gingival crevicular fluid forms a useful analyte for detecting SARS-CoV-2 antibody. |
• | There are differential patterns of antibody reactivity across NP and Spike. |
• | Higher antibody levels in early acute phase linked to severity of COVID-19. |
Plan
© 2022
Publié par Elsevier Masson SAS.
Vol 85 - N° 2
P. 152-160 - août 2022 Retour au numéro
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