Statin Use in Hospitalized Patients with COVID-19: A Comprehensive Analysis of the New York City Public Hospital System - 16/06/22
, Sanjana Nagraj, MD a, Adrija Hajra, MD a, Tinatin Saralidze, MD a, Dimitrios Varrias, MD a, Sheetal Vasundara Mathai, MD a, Marko Novakovic, MD a, Kenneth H. Hupart, MD b, Jeremy A. Miles, MD a, Adarsh Katamreddy, MD a, Leonidas Palaiodimos, MD a, Robert T. Faillace, MD a
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Abstract |
Introduction |
Statins have been commonly used for primary and secondary cardiovascular prevention. We hypothesized that statins may improve in-hospital outcomes for hospitalized patients with Coronavirus disease 2019 (COVID-19) due to its known anti-inflammatory effects.
Methods |
We conducted a retrospective study at the largest municipal health care system in the United States, including adult patients who were hospitalized for COVID-19 between March 1 and December 1, 2020. The primary endpoint was in-hospital death. Propensity score matching was conducted to balance possible confounding variables between patients receiving statins during hospitalization (statin group) and those not receiving statins (non-statin group). Multivariate logistic regression was used to evaluate the association of statin use and other variables with in-hospital outcomes.
Results |
There were 8897 patients eligible for study enrollment, with 3359 patients in the statin group and 5538 patients in the non-statin group. After propensity score matching, both the statin and non-statin groups included 2817 patients. Multivariate logistic regression analysis showed that the statin group had a significantly lower risk of in-hospital mortality (odds ratio 0.71; 95% confidence interval, 0.63-0.80; P < .001) and mechanical ventilation (OR 0.80; 95% confidence interval, 0.71-0.90; P < .001) compared with the non-statin group.
Conclusion |
Statin use was associated with lower likelihood of in-hospital mortality and invasive mechanical ventilation in hospitalized patients with COVID-19.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, In-hospital mortality, Mechanical ventilation, Statin
Plan
| Funding: None. |
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| Conflicts of Interest: None. |
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| Authorship: All authors had access to the data and contributed to writing the manuscript. |
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| This work was approved by the Biomedical Research Alliance of New York (BRANY) Institutional Review Board (IRB number 20-12-228-373). |
Vol 135 - N° 7
P. 897-905 - juillet 2022 Retour au numéro
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