Complete Pathologic Response to Pembrolizumab and Axitinib in a Patient With Sarcomatoid RCC and Ocrelizumab-Treated Multiple Sclerosis - 13/06/22
Doi : 10.1016/j.urology.2021.12.015
Kevin Neuzil 1, Kathryn Gessner 1, John Hedgepeth 2, Sara E. Wobker 2, Eric M. Wallen 1, 3, Katherine P. Morgan 4, 5, Marc A. Bjurlin 1, 3, Tracy L. Rose 3, 6, ⁎ 
1 Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC
2 Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC
3 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
4 Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC
5 Department of Practice Advancement and Clinical Education, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC
6 Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁎Address correspondence to: Tracy L. Rose, M.D., M.P.H., Division of Oncology, University of North Carolina at Chapel Hill, 170 Manning Drive CB 7305, Chapel Hill, NC 27599Division of OncologyUniversity of North Carolina at Chapel Hill170 Manning Drive CB 7305Chapel HillNC27599
Abstract |
Non–clear cell renal cell carcinoma (RCC) is a heterogeneous disease. We report a case of sarcomatoid non–clear cell RCC in a patient with underlying multiple sclerosis (MS) on immunosuppression with a complete pathologic response to pembrolizumab and axitinib. Comprehensive genomic profiling revealed pathogenic mutations in SETD2 and TP53 with high RNA expression levels of immune checkpoint proteins. Our case illustrates the importance of treatment selection based on presence of sarcomatoid features, underlying autoimmune disease, and genomic profiling.
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Vol 164
P. 50-54 - juin 2022 Retour au numéro
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