Endoscopic ultrasound guided fine needle biopsy in patients with suspected gastric linitis plastica - 10/06/22
, Benoit Terris b, d, Lola-Jade Palmieri a, d, Alexandre Rouquette b, Frédéric Beuvon b, Anna Pellat a, d, Einas Abou Ali a, d, Claire Ginestet a, d, Arthur Belle a, Dr Marion Dhooge a, Dr Catherine Brezault a, Rachel Hallit a, Anthony Dohan c, d, Stanislas Chaussade a, d, Romain Coriat a, d, Maximilien Barret a, dHighlights |
• | The infiltrative character of gastric linitis plastica (GLP) lead to a late diagnosis and non-conclusive mucosal biopsies. |
• | We revealed that lymph node or gastric parietal biopsies guided by EUS in the setting of suspected gastric cancer have a considerable high sensitivity. |
• | EUS-FNB could be proposed early in the diagnostic workup instead of repeating mucosal biopsies. |
Abstract |
Background |
Gastric linitis plastica (GLP) is a diffuse infiltrating type of gastric adenocarcinoma. It is associated with a poor prognosis and a five-year survival of 3–10%. The infiltrating profile of this tumor explains the low yield of the superficial mucosal biospies. The objective of this study was to investigate the role of endoscopic ultrasound-fine needle biopsy (EUS-FNB) in the diagnosis of GLP.
Methods |
We performed a retrospective analysis including all patients who had an EUS-FNB, at a tertiary referral center, over the last 3 years. The primary outcome was the sensitivity of EUS-FNB in patients with suspected GLP.
Results |
Between January 2017 and December 2020, 34 patients had an EUS-FNB for suspected GLP. Ten patients had a diagnostic of GLP. This diagnosis was obtained by EUS-FNB in 90% (9/10) of the cases. Eight patients had at least one previous esophagogastroduodenoscopy (EGD) with negative mucosal biopsies. Gastric EUS-FNB helped diagnose other serious conditions in 47% (16/34) of cases with inconclusive mucosal biopsies.
Conclusion |
Gastric EUS-FNB in patients with suspected GLP and normal endoscopic mucosal biopsies may lead to a positive diagnosis of GLP in 90% of cases without notable adverse events. This technique should be considered as a second step in the setting of suspicion of GLP after inconclusive mucosal biopsies.
Le texte complet de cet article est disponible en PDF.Keywords : Gastric linitis plastica, Gastric adenocarcinoma, Endoscopic ultrasound, Fine needle biopsy, Poorly cohesive cells
Plan
| All authors have seen and approved the final version of the manuscript being submitted. The authors have no conflicts of interest to declare that are relevant to the content of this article. |
Vol 46 - N° 5
Article 101903- mai 2022 Retour au numéro
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