Reduced neutralizing antibody response in naïve Covishield vaccinees against Omicron emphasizes booster vaccination - 09/06/22
Doi : 10.1016/j.jinf.2022.04.031
Pragya D. Yadav a, ⁎, # 
, Gajanan N. Sapkal a, #, Rima R. Sahay a, #, Deepak Y. Patil a, Sachee Agrawal b, Balkrishna Adsul c, Srikanth Tripathy d, Gururaj R. Deshpande a, Dimpal A. Nyayanit a, Anita M. Shete a, Manish Manraie e, Sanjay Kumar f, Jayanthi Shastri b, Priya Abraham a
, Gajanan N. Sapkal a, #, Rima R. Sahay a, #, Deepak Y. Patil a, Sachee Agrawal b, Balkrishna Adsul c, Srikanth Tripathy d, Gururaj R. Deshpande a, Dimpal A. Nyayanit a, Anita M. Shete a, Manish Manraie e, Sanjay Kumar f, Jayanthi Shastri b, Priya Abraham a a Indian Council of Medical Research-National Institute of Virology, Pune, India
b Kasturba Hospital for Infectious Diseases, Mumbai, Maharashtra, India
c Seven Hills Hospital, Mumbai, Maharashtra, India
d Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India
e Armed Forces Medical College, Pune, Maharashtra, India
f Command Hospital (South Command), Pune, Maharashtra, India
⁎Corresponding author at: Scientist ‘F’ and Group Leader, Maximum Containment Facility, Indian Council of Medical Research- National Institute of Virology, Sus Road, Pashan, Pune 411021, India.Scientist ‘F’ and Group Leader, Maximum Containment FacilityIndian Council of Medical Research- National Institute of VirologySus Road, PashanPune411021India
Highlights |
• | Immune response was assessed in the sera of covishield vaccinees. |
• | IgG response in naïve vaccinees was lesser than recovered and breakthrough cases. |
• | Neutralizing antibody titre for naïve vaccinees was lowest with omicron. |
• | Breakthrough cases demonstrated highest neutralizing antibody titre with omicron. |
• | The study demonstrated need for booster dose in naïve vaccinees. |
Plan
© 2022
Publié par Elsevier Masson SAS.
Vol 85 - N° 1
P. 90-122 - juillet 2022 Retour au numéro
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