Sleep Deficiency and Opioid Use Disorder : Trajectory, Mechanisms, and Interventions - 31/05/22

Doi : 10.1016/j.ccm.2022.05.001

Jennifer Langstengel, MD ^a, H. Klar Yaggi, MD, MPH ^a,^b,^⁎
^a Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208057, New Haven, CT 06520-8057, USA
^b Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA

^∗Corresponding author. Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208057, New Haven, CT 06520-8057.Department of Internal MedicineSection of Pulmonary, Critical Care, and Sleep MedicineYale University School of Medicine300 Cedar Street, PO Box 208057New HavenCT06520-8057

Résumé

Opioid use disorder (OUD) is a chronic and relapsing brain disease characterized by loss of control over opioid use and impairments in cognitive function, mood, pain perception, and autonomic activity. Sleep deficiency, a term that encompasses insufficient or disrupted sleep due to multiple potential causes, including sleep disorders (eg, insomnia, sleep apnea), circadian disruption (eg, delayed sleep phase and social jet lag), and poor sleep quality (eg, sleep fragmentation, impaired sleep architecture), is present in greater than 75% of patients with OUD. This article focuses on highlighting bidirectional mechanisms between OUD and sleep deficiency and points toward promising therapeutic targets.

Le texte complet de cet article est disponible en PDF.

Keywords : Opioid use disorder, Sleep deficiency, Control of breathing