Tuberculosis and autoimmunity: Common features - 28/05/22

Doi : 10.1016/j.tube.2022.102202

A. Starshinova ^a,^⁎ , А. Malkova ^b , I. Kudryavtsev ^c , D. Kudlay ^d,^e , Yu Zinchenko ^f , P. Yablonskiy ^b,^f
^a Head of the Research Department, Almazov National Medical Research Centre, 2, Akkuratov str, Saint-Petersburg, 197341, Russia
^b Laboratory of the Mosaic of Autoimmunity, St-Petersburg State University, 7-9, University Embankment, Saint-Petersburg, 199034, Russia
^c Laboratory of the Mosaic of Autoimmunity, St. Petersburg State University, Institution of Experimental Medicine, department of Immunology, acad. Pavlov str., 12, 197376, St. Petersburg, Russia
^d Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Russian Federation, Laboratory of Personalized Medicine and Molecular Immunology, 24, Kashirskoye highway, Moscow, 115552, Russia
^e NRC Institute of Immunology FMBA of Russia, 24, Kashirskoye highway, Moscow, 115552, Russia
^f St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, Ligovskii prospect, 2-4, Saint-Petersburg, 191036, Russia

^∗Corresponding author.

Abstract

Despite the proven infectious nature of tuberculosis, new data have recently appeared on the autoimmune component in the course of tuberculosis infection. This chapter discusses the currently known signs of autoimmune inflammation in tuberculosis infection, including both clinical and immunological manifestations. Taking into account the available data on the possible triggering effect of M. tuberculosis on the development of the autoimmune process, the correction of these autoimmune complications may be a key moment in prescribing therapy and in predicting the low efficacy of the treatment of the disease.

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Keywords : Tuberculosis, Autoimmunity, Molecular mimicry, Autoantibodies, HLA, ASIA

Plan

Introduction

Immunological characteristics of tuberculosis as an autoimmune disease

Imbalance of T- and B-lymphocytes

T follicular helpers and T helpers cells

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Vol 134

Article 102202- mai 2022 Retour au numéro

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Tuberculosis and autoimmunity: Common features - 28/05/22

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