Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis - 20/05/22
Doi : 10.1016/j.jinf.2022.03.020
Jialin Meng a, 1, Qintao Ge a, 1, Jiawei Li a, 1, Xiaofan Lu b, c, Yonghao Chen d, Haitao Wang e, Meng Zhang a, Juan Du f, g, Li Zhang a, Zongyao Hao a, ⁎ 
, Chaozhao Liang a, ⁎
, Chaozhao Liang a, ⁎ a Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Medical University, Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, 218th Jixi Road, Hefei, Anhui 230022, China
b State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 211198, China
c Department of Cancer and Functional Genomics, Institute of Genetics and Molecular and Cellular Biology, CNRS/INSERM/UNISTRA, Illkirch 67400, France
d Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
e Center for Cancer Research, Clinical Research/NCI/NIH, Bethesda, MD 20892, United States
f School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China
g Longgang District People's Hospital of Shenzhen and The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China
⁎Corresponding author at: Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Medical University, Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, 218th Jixi Road, Hefei, Anhui 230022, China.Department of UrologyThe First Affiliated Hospital of Anhui Medical UniversityInstitute of UrologyAnhui Medical University, Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University218th Jixi RoadHefeiAnhui230022China
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Highlights |
• | Receiving anti-androgen therapy can prevent the infection with SARS-CoV-2. |
• | COVID-19 patients can benefit from the anti-androgen therapy with less death. |
• | Androgen receptor regulates TMPRSS2 and ACE2 expression to reduce the effects of SARS-CoV-2. |
Plan
© 2022
Elsevier Ltd. Tous droits réservés.
Vol 84 - N° 6
P. 834-872 - juin 2022 Retour au numéro
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