Lower Airway Nitrogen Oxide Levels in Children with Primary Ciliary Dyskinesia Is Linked to Neutrophilic Inflammation - 06/05/22
Doi : 10.1016/j.jpeds.2022.01.040
Hartmut Grasemann, MD 1, 2, 3, ⁎ 
, Nancy McDonald, MScN 1, 3, Xi Zhou Yuan, MSc 2, 3, Sharon Dell, MD 1, 3, 4, Valerie Waters, MD 2, 3, 5, Felix Ratjen, MD 1, 2, 3
, Nancy McDonald, MScN 1, 3, Xi Zhou Yuan, MSc 2, 3, Sharon Dell, MD 1, 3, 4, Valerie Waters, MD 2, 3, 5, Felix Ratjen, MD 1, 2, 3 1 Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
2 Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
3 University of Toronto, Toronto, Ontario, Canada
4 Division of Respiratory Medicine, Department of Pediatrics, University of British Columbia, British Columbia, Canada
5 Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
∗Reprint requests: Hartmut Grasemann, MD, Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Ave, Toronto, Ontario, M5G 1X8 Canada.Division of Respiratory MedicineDepartment of PaediatricsThe Hospital for Sick Children and University of Toronto555 University AveTorontoOntarioM5G 1X8Canada
Abstract |
Treatment of primary ciliary dyskinesia pulmonary exacerbations resulted in an increase in sputum nitric oxide (NO) metabolites and decrease in neutrophilic inflammation. The association between the 2 suggests that neutrophilic inflammation contributes to airway NO deficiency in primary ciliary dyskinesia and that reducing inflammation may lead to improved airway NO homeostasis.
Trial Registry |
ClinicalTrials.gov: NCT01155115.
Le texte complet de cet article est disponible en PDF.Key words : nitric oxide, cystic fibrosis, lung disease, biomarker
Abbreviations : ADMA, CF, FEV1, IL-8, NE, NO, NOS, PCD, PEx
Plan
| The authors declare no conflicts of interest. |
© 2022
Elsevier Inc. Tous droits réservés.
Vol 244
P. 230-233 - mai 2022 Retour au numéro
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