The value of electrostatic potentials of the spike receptor binding and N-terminal domains in addressing transmissibility and infectivity of SARS-CoV-2 variants of concern - 05/05/22
Highlights |
• | The net surface charge(EP) of SARS-CoV-2 (S) RBD and NTD are generally positive. |
• | The EP of SARS-CoV-2 (S) RBD increases in keeping with variants transmissibility. |
• | Omicron B.A1 variant has the highest EP of SARS-CoV-2 (S) RBD. |
• | Omicron B.A1 is the only variant with a negative EP of (S) NTD. |
Graphical abstract |
Comparison of the surface electrostatic potential of the N-terminal (NTD) and the Receptor Binding Domains (RBD) of the Wuhan and Omicron Spikes. The entire Spikes are represented with transparent ribbon models. Only the NTD and RBD surfaces of the chain A are represented. Domain net charges are reported within parenthesis beside the domain labels. Surface color ranges from -5.0 (red) to + 5.0 (blue) kT/e.
Abbreviations : EPrbd, EPntd
Vol 84 - N° 5
P. e62-e63 - mai 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.