Systematic comparison between BNT162b2 and CoronaVac in the seroprotection against SARS-CoV-2 Alpha, Beta, Gamma, and Delta variants - 05/05/22
Doi : 10.1016/j.jinf.2022.02.030
Wing Ying Au a, b, 1, Chengjin Ye c, 1, Sydney Leigh Briner d, Gianmarco Domenico Suarez e, Jeewon Han e, Xinzhou Xu a, b, Jun-Gyu Park c, Melinda Ann Brindley d, Luis Martinez-Sobrido c, ⁎ 
, Peter Pak-Hang Cheung a, b, ⁎
, Peter Pak-Hang Cheung a, b, ⁎ a Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
b Li Ka Shing Institute of Health Sciences, Li Ka Shing Medical Sciences Building, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
c Texas Biomedical Research Institute, San Antonio, Texas, U.S.A.
d Department of Infectious Diseases, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia, U.S.A.
e Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
⁎Corresponding author at: The Chinese University of Hong Kong, Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.The Chinese University of Hong KongDepartment of Chemical PathologyFaculty of Medicine, Prince of Wales HospitalShatinNew TerritoriesHong Kong
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Highlights |
• | Sera from BNT162b2 recipients seroprotects more than Coronavac. |
• | While BNT162b2 seroprotect Beta less, Coronavac protects against all variants similarly to original WA1 strain. |
• | Antibodies elicited by Cornavac can bind to both Spike and Nucleocapsid, whereas BNT162b2 could only bind to spike. |
Plan
© 2022
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 84 - N° 5
P. e55-e57 - mai 2022 Retour au numéro
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