The novel hamster-adapted SARS-CoV-2 Delta variant may be selectively advantaged in humans - 05/05/22
Doi : 10.1016/j.jinf.2022.03.001
Jacques Fantini a, Christian A. Devaux b, c, Nouara Yahi a, Roger Frutos d, ⁎ 
a INSERM UMR_S 1072 and Aix Marseille Université, Marseille, France
b MEPHI, IRD, Marseille, France
c CNRS, Marseille, France
d CIRAD, UMR 17, Intertryp, Montpellier
⁎Corresponding author. Roger Frutos, CIRAD, Intertryp, UMR 17, Campus International de Baillarguet, 34398 Montpellier Cedex5, France.CIRAD, Intertryp, UMR 17Campus International de BaillarguetMontpellierCedex534398France
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Highlights |
• | The D427G mutation optimizes the ACE2 interaction. |
• | The variant is adapted to hamsters. |
• | The same variant is potentially favored on humans. |
• | There is a risk of novel variant emergence. |
• | This hamster-adapted variant must be monitored. |
Graphical abstract |
Keywords : COVID-19, SARS-CoV-2, ACE2, Spike, selective advantage, hamsters, humans, Hong Kong
Plan
© 2022
Publié par Elsevier Masson SAS.
Vol 84 - N° 5
P. e53-e54 - mai 2022 Retour au numéro
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