Intra-host SARS-CoV-2 single-nucleotide variants emerged during the early stage of COVID-19 pandemic forecast population fixing mutations - 05/05/22
Doi : 10.1016/j.jinf.2022.01.016
Yi Zhang a, #, Ning Jiang a, d, #, Weiqiang Qi b, #, Tao Li b, #, Yumeng Zhang a, Haocheng Zhang a, Jing Wu a, Zhaoqin Zhu b, ⁎ 
, Jingwen Ai a, ⁎ , Chao Qiu a, c, ⁎ , Wenhong Zhang a, c, d, e, ⁎
, Jingwen Ai a, ⁎ , Chao Qiu a, c, ⁎ , Wenhong Zhang a, c, d, e, ⁎ a Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China
b Shanghai Public Health Clinical Center, Shanghai, China
c Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China
d State Key Laboratory of Genetic Engineering and Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, China
e Key Laboratory of Medical Molecular Virology (MOE/MOH), Shanghai Medical College, Fudan University, Shanghai, China
⁎Corresponding authors.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Highlights |
• | A large proportion of iSNVs could be found in the several dominant VOCs in early-stage samples. |
• | iSNVs located spike protein may help in immune escape forecasting. |
• | The dominant C-U/G-A in iSNVs indicate APOBEC driven SARS-CoV-2 to adaptation. |
Keywords : SARS-CoV-2, Intra-host single-nucleotide variants, COVID-19, Fixed mutation
Plan
© 2022
Publié par Elsevier Masson SAS.
Vol 84 - N° 5
P. 722-746 - mai 2022 Retour au numéro
Article précédent
- Host-cell recognition through Cs-GRP78 is enhanced in the new Omicron variant of SARS-CoV-2, in silico structural point of view
- Abdo A Elfiky, Ibrahim M Ibrahim
- Persistent Post COVID-19 Symptoms and Functional Status after 12-14 weeks of recovery, Tamil Nadu, India, 2021
- Polani Rubeshkumar, Alby John, Manish Narnaware, Jagadeesan M, Fermi Vidya, Rajeshkumar Gurunathan, Parasuraman Ganeshkumar, Gagandeep Singh Bedi, Prabhdeep Kaur
Bienvenue sur EM-consulte, la référence des professionnels de santé.