The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021 : A Systematic Review - 23/04/22

Doi : 10.1016/j.iac.2022.01.004

Fatima Bassir, MPH ^a,^b,^{^{1
F. Bassir and S. Varghese have contributed equally to this work.},}^⁎ , Sheril Varghese, B.A. ^a,^{^{1
F. Bassir and S. Varghese have contributed equally to this work.}}, Liqin Wang, PhD ^c, Yen Po Chin, MD, MBI ^c, Li Zhou, MD, PhD ^c
^a Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, 399 Revolution Drive, Suite 1315, Somerville, MA 02145, USA
^b Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital, 399 Revolution Drive, Suite 1315, Somerville, MA 02145, USA
^c Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 399 Revolution Drive, Suite 1315, Somerville, MA 02145, USA

^∗Corresponding author. Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital, 399 Revolution Drive, Suite 1315, Somerville, MA 02145.Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital399 Revolution Drive, Suite 1315SomervilleMA02145

Résumé

Electronic health records (EHRs) have revolutionized the field of drug hypersensitivity reaction (DHR) research. In this systematic review, we assessed 140 articles from 2000-2021, classifying them under six themes: observational studies (n=61), clinical documentation (n=27), case management (n=22), clinical decision support (CDS) (n=18), case identification (n=9), and genetic studies (n=3). EHRs provide convenient access to millions of medical records, facilitating epidemiological studies of DHRs. Though the goal of CDS is to promote safe drug prescribing, allergy alerts must be designed and used in a way that supports this effort. Ultimately, accurate allergy documentation is essential for DHR prevention.

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Keywords : Drug hypersensitivity, Electronic health record, Allergy documentation, Drug allergy label, Allergy epidemiology

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	Author Contributions: Please see author statement.
	This research was supported with funding from the Agency for Healthcare Research and Quality (AHRQ) grant R01HS025375 and the National Institute of Allergy and Infectious Diseases (NIAID) of National Institute of Health (NIH) grant 1R01AI150295.

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Vol 42 - N° 2

P. 453-497 - mai 2022 Retour au numéro

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The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021 : A Systematic Review - 23/04/22

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