Advances in the Pathomechanisms of Delayed Drug Hypersensitivity - 23/04/22

Doi : 10.1016/j.iac.2022.01.002

Chuang-Wei Wang, PhD ^a,^b,^c, Sherrie Jill Divito, MD, PhD ^d, Wen-Hung Chung, MD, PhD ^a,^b,^c,^e,^f,^⁎ , Shuen-Iu Hung, PhD ^a,^b,^g,^⁎
^a Cancer Vaccine & Immune Cell Therapy Core Lab, Department of Medical Research, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan
^b Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan
^c Department of Dermatology, Xiamen Chang Gung Hospital, No. 123, Xiafei Road, Haicang District, Xiamen, China
^d Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Avenue, EBRC Room 513, Boston, MA 02115, USA
^e Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung Branch, No. 222, Maijin Rd., Anle Dist., Keelung 204, Taiwan
^f College of Medicine, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan 333, Taiwan
^g Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 112 Taiwan

^∗Corresponding author. Department of Medical Research, Cancer Vaccine & Immune Cell Therapy Core Lab, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Medical ResearchCancer Vaccine & Immune Cell Therapy Core LabChang Gung Memorial HospitalLinkou BranchTaoyuan333Taiwan

Résumé

Delayed drug hypersensitivity continues to contribute to major clinical problems worldwide. The clinical presentations of delayed drug hypersensitivity are diverse, ranging from mild skin rashes to life-threatening systemic reactions. The pathomechanism of delayed drug hypersensitivity involves human leukocyte antigens (HLA) presentation of drugs/metabolites to T cell receptors (TCR), resulting in T-cell activation. The pathogenesis of delayed drug hypersensitivity also has reactivation of the virus, and activation of many immune mediators. In this review, we discuss the immune pathogenesis, molecular interactions of HLA/drugs/TCR, and downstream signaling of cytotoxic proteins/cytokines/chemokines, as well as disease prevention and management for delayed drug hypersensitivity.

Le texte complet de cet article est disponible en PDF.

Keywords : Delayed drug hypersensitivity, Human leukocyte antigens, Immune checkpoint blockade, Severe cutaneous adverse reactions, T cell receptor, Cytotoxic proteins