RNA viral loads of SARS-CoV-2 Alpha and Delta variants in nasopharyngeal specimens at diagnosis stratified by age, clinical presentation and vaccination status - 08/04/22
Doi : 10.1016/j.jinf.2021.12.018
Rosa Costa a, Beatriz Olea a, María Alma Bracho b, Eliseo Albert a, Paula de Michelena a, Cecilia Martínez-Costa c, d, Fernando González-Candelas b, David Navarro a, e, ⁎ 
a Department of Microbiology, Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, University of Valencia, Av. Blasco Ibáñez 17, Valencia 46010, Spain
b CIBER in Epidemiology and Public Health Spain; Joint Research Unit "Infection and Public Health" FISABIO-University of Valencia Valencia Spain; Institute for Integrative Systems Biology (I2SysBio), CSIC-University of Valencia, Valencia, Spain
c Department of Pediatrics, Hospital Clínico Universitario, Valencia, Spain
d Department of Pediatrics, University of Valencia, Valencia, Spain
e Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain
⁎Correspondence author at: Department of Microbiology, Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, University of Valencia, Av. Blasco Ibáñez 17, Valencia 46010, Spain.Department of MicrobiologyMicrobiology ServiceClinic University HospitalINCLIVA Health Research InstituteUniversity of ValenciaAv. Blasco Ibáñez 17Valencia46010Spain
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Highlights |
• | Overall, higher SARS-CoV-2 RNA loads are seen for the delta variant compared to the alpha variant within 2 days after symptoms onset. |
• | SARS-CoV-2 RNA loads were higher for the delta than the alpha variant, in both asymptomatic adults and children. |
• | For COVID-19 patients, SARS-CoV-2 delta RNA loads were higher in non-vaccinated individuals compared with vaccinated participants. |
• | Asymptomatic vaccinated and unvaccinated individuals displayed similar SARS-CoV-2 delta RNA loads. |
Keywords : SARS-CoV-2 RNA load, B.1.1.7 variant, B.617.2 variant, Upper respiratory tract, COVID-19
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© 2021
Publié par Elsevier Masson SAS.
Vol 84 - N° 4
P. 579-613 - avril 2022 Retour au numéro
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