Do diabetic complications influence cancer-related events in people with type 2 diabetes? A cohort approach - 24/03/22
, Pierre-Jean Saulnier b, Elise Gand b, Gautier Defossez b, c, Amélie Jamet a, Stéphanie Ragot b, Marc Paccalin a, b, 1, Samy Hadjadj d, 1for the
SURDIAGENE study group
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Highlights |
• | Type 2 diabetes represents a risk factor for developing several types of cancer. |
• | Diabetes and cancer share common risk factors, which also lead to micro- and macrovascular diabetes complications. |
• | Micro and/or macrovascular diabetes complications were not associated with cancer outcomes. |
• | Higher risk of cardiovascular death was associated with history of cancer in people with type 2 diabetes. |
Abstract |
Aim |
To investigate whether diabetic micro- and macrovascular complications (mMVC) influence cancer-related events in people with type 2 diabetes.
Methods |
People with type 2 diabetes from the SURDIAGENE cohort were characterized (duration of diabetes, HbA1c, mMVC, history of cancer) and prospectively followed-up for death and cancer-related events (occurrence, dissemination and cancer-related death).
Results |
Between 2002 and 2012, 1468 participants (58% men, mean age 64.8 ± 10.7 years, mean duration of diabetes 14.5 ± 9.9 years at baseline) were enrolled. At baseline, 119 (8%) had a personal history of cancer. Incident cancer occurred in 207 (14%) patients during a mean follow-up of 7.3 ± 3.7 years and was associated with older age, smoking status and personal history of cancer. mMVC were not associated with cancer-related events, considering cancer occurrence, node/metastasis dissemination and cancer-specific death. Risk of all-cause mortality was increased in diabetic patients cumulating cancer history and mMVC (HR 1.73, 95%CI 1.25-2.38) compared to those with neither cancer nor mMVC. In our cohort, cancer-related death was not associated with mMVC (HR 1.05, 95%CI 0.67-1.64), but conversely history of cancer was significantly associated with cardiovascular-related death (HR 2.41, 95%CI 1.36-4.26).
Conclusion |
In our cohort, mMVC were not associated with cancer-related events, while history of cancer was significantly associated with cardiovascular death.
Le texte complet de cet article est disponible en PDF.Keywords : Cancer, Diabetic complications, Macrovascular complications, Microvascular complications, Prognosis, type 2 diabetes
Abbreviations : CI, DKD, DR, eGFR, HR, ICD-10, RGCPC, SEER, SURDIAGENE, uACR, WHO
Plan
Vol 48 - N° 2
Article 101289- mars 2022 Retour au numéro
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