Functional imaging plays a central role in the management of thyroid cancer patients.

In patients with a differentiated thyroid cancer (DTC), radioactive iodine (RAI) is used mostly with a therapeutic intent, either post-operatively or as the first line systemic treatment in patients with known structural disease. A whole body scan is performed a few days after the RAI administration, and this procedure is very sensitive to detect all tumor foci with RAI uptake. PET/CT with ¹⁸F-FDG complements the use of RAI at the initial evaluation of patients with high-risk DTC, during follow-up in those with rising serum thyroglobulin levels over time, for the work-up of patients with documented structural disease and for assessing the efficacy of focal or systemic treatment modalities. ¹⁸F-FDG uptake is a prognostic indicator in all these clinical conditions. A dosimetric approach with ¹²⁴I PET/CT showed encouraging results.

Several functional imaging modalities are currently available for medullary thyroid carcinoma (MTC) patients. ¹⁸F-FDG-PET/CT may be sensitive in MTC patients with high FDG uptake that signals aggressive disease. ¹⁸F-DOPA is the most sensitive imaging technique to visualize small tumor foci, and is also highly specific in patients with a known MTC, but should be complemented by a CT scan of the chest and by a MRI of the liver to detect small metastases.