Impact of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) rectal carriage in cancer patients admitted to the intensive care unit - 27/02/22
, Maider Coppry c, Eva Ripoche a, Olivier Guisset a, Gaelle Mourissoux a, Emile Bessede d, Fabrice Camou a, bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | The rate of ESBL-E colonization in ICU cancer patients is not well known. |
• | Rectal ESBL-E colonization in ICU cancer patients remains rare. |
• | Infections caused by ESBL-E colonization are rare, but they are associated with high mortality. |
• | Detecting fecal carriage with ESBL-E helps to identify high-risk populations and to guide antibiotic prescription in severe infections. |
Abstract |
Little data is available on extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) rectal colonization in cancer patients admitted to the intensive care unit (ICU). We aimed to describe the epidemiology of ESBL-E in cancer patients hospitalized in the ICU compared with non-cancer patients. ESBL-E colonization was detected in 6.6% of 1,013 cancer patients and 6.4% of 1625 non-cancer patients. At admission, among the 172 colonized patients: 48/67 cancer patients and 78/105 non-cancer patients developed an infection, documented with an ESBL-E for 21% and 24% of them, respectively. The in-hospital mortality rate among colonized patients was 33% in cancer patients and 12% in non-cancer patients. In cancer patients, ESBL-E infections are rare but systematic rectal screening identifies high-risk population and guides empirical antibiotic therapy. It also contributes to being aware of the ICU microbiological ecology.
Le texte complet de cet article est disponible en PDF.Keywords : Colonization, Infection, ESBL-E, Cancer patients
Plan
Vol 52 - N° 2
P. 104-106 - mars 2022 Retour au numéro
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