Emerging Knowledge of the Neurobiology of COVID-19 - 24/02/22
, Benjamin Cross, MD b, Danish Hafeez c, Mao Fong Lim, MD d, Hamilton Morrin, MD e, Emma Rachel Rengasamy, MD f, Tom Pollak, PhD a, Timothy R. Nicholson, PhD a
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Résumé |
Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and “long COVID,” which occurs in many patients with a milder acute COVID-19 illness.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, SARS-CoV-2, Neurobiology, Delirium, Long COVID, Neuropsychiatry
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| Conflict of interest: The authors declare no commercial or financial conflicts of interest. |
Vol 45 - N° 1
P. 29-43 - mars 2022 Retour au numéro
Article précédent
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