To evaluate, primary the effects of Micro-osteoperforation (MOP) on orthodontically induced inflammatory root resorption (OIIRR) of maxillary first molars, and secondary, the density of surrounding alveolar bone during distalization phase with Fast Back distalizer.

Female patients between 16–20 years of age (University of Mansoura), meeting the criteria, were included between March to September 2019. They were randomly, and equally allocated into control and MOP groups. Both of them underwent distalization with Fast Back distalizer. 3MOPs were applied in the intervention group, distal to the first molars using a 3D printed guide. CBCT images were obtained before and after distalization. Apical root resorption maxillary first molars’ roots, and alveolar bone density surrounding them were evaluated using independent-samples t-test. Time of distalization phase was assessed using Mann–Whitney U test. Correlation and partial correlation tests were done between resorption of roots, bone density, and time.

Screening of 50 patients, and exclusion for 30 of them were done. Only 20 subjects underwent the trial to the end. In MOP group, OIIRR of mesiobuccal roots significantly increased (MD=−0.2 (−0.34 to −0.01), P<0.05), and significantly decreased for disto-buccal roots (MD=0.6 (0.45 to 0.72), P<0.001). The second and third layers of bone density decreased significantly in MOP group (MD=116.7 (50.8 to 182.5), MD=560.4 (327.9 to 792.7) respectively, P<0.001). Time for distalization phase was significantly reduced in MOP group (P<0.001).

MOP decreased OIIRR for nearby distobuccal roots by reduction in surrounding density of bone, and increased OIIRR for the far mesiobuccal roots.