Post-sequelae one year after hospital discharge among older COVID-19 patients: A multi-center prospective cohort study - 14/02/22
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Highlights |
• | Prevalence rate of main sustained sequelae including fatigue, chest tightness, myalgia, and cough dropped significantly, but still cannot be ignored. |
• | New sequelae among older COVID-19 patients require adequate attention and appropriate intervention. |
• | Disease severity during hospitalization, age, and follow-up time contributed significantly to the risk of post-sequelae and CAT scoring one year after hospital discharge among older COVID-19 patients. |
Abstract |
Background |
To systematically evaluate the prevalence of post-sequelae and chronic obstructive pulmonary disease assessment test (CAT) scoring one year after hospital discharge among older COVID-19 patients, as well as potential risk factors.
Methods |
A multi-center prospective cohort study involving 1,233 eligible older COVID-19 patients was conducted. All patients were followed-up between Mar 1, 2021 and Mar 20, 2021. CAT scoring was adopted to measure symptom burden in COVID-19 patients.
Results |
Of the 1233 eligible cases, 630 (51.1%) reported at least one sequelae. The top six post-sequelae included fatigue (32.4%), sweating (20.0%), chest tightness (15.8%), anxiety (11.4%), myalgia (9.0%), and cough (5.8%). Severe patients had significantly higher percentage of fatigue, sweating, chest tightness, myalgia, and cough (P<0.05), while anxiety was universal in all subjects. Sweating, anxiety, palpitation, edema of lower limbs, smell reduction, and taste change were emerging sequelae. Disease severity during hospitalization (OR: 1.46, 95% CI: 1.15–1.84, P = 0.002), and follow-up time (OR: 0.71, 95% CI: 0.50–0.99, P = 0.043) were independently associated with risk of post-sequelae, while disease severity during hospitalization was significantly associated with increased risk of emerging sequelae (OR: 1.33, 95% CI: 1.03–1.71, P = 0.029). The median of CAT score was 2 (0–5) in all patients, and a total of 120 patients (9.7%) had CAT scores ≥10. Disease severity during hospitalization (OR: 1.81, 95% CI: 1.23–2.67, P = 0.003) and age (OR: 1.07, 95% CI: 1.04–1.09, P<0.001) were significantly associated with increased risk of CAT scores ≥10.
Conclusions |
While the dramatic decline in the prevalence rate of persistent symptoms is reassuring, new sequelae among older COVID-19 patients cannot be ignored. Disease severity during hospitalization, age, and follow-up time contributed to the risk of post-sequelae and CAT scoring one year after hospital discharge among older COVID-19 patients. Our study provides valuable clues for long-term post-sequelae of the older COVID-19 patients, as well as their risk factors.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, Sequelae, Older people, Wuhan, SARS-CoV-2
Plan
Vol 84 - N° 2
P. 179-186 - février 2022 Retour au numéro
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