Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection - 10/02/22
, Yu-Fan Cheng d, Jing-Houng Wang a, Yi-Hao Yen a, ⁎, 1 , Ting-Ting Liu b, e, Wei-Feng Li c, Chien-Hung Chen aAbstract |
Background |
Large well-differentiated hepatocellular carcinoma (HCC) ≥ 3 cm (defined as atypical HCC) is uncommon. We evaluated the characteristics and outcomes of atypical HCC patients underwent liver resection (LR).
Methods |
This retrospective study enrolled patients who underwent LR for HCC from 2007 to 2017. Patient characteristics and overall survival (OS) were compared between patients with atypical HCC and patients with typical HCC (moderate-to-undifferentiated HCC ≥ 3 cm).
Results |
Among 598 patients, 51 (8.5%) had atypical HCC. Patients with atypical HCC had higher rates of non-hepatitis B or C infections (p = 0.02) and American Joint Committee on Cancer T1 pathology (p < 0.001), a lower rate of alpha-fetoprotein >20 ng/ml (p < 0.001) and a longer OS (p < 0.001) than those with typical HCC. Multivariate analysis showed that atypical HCC was associated with OS (HR = 0.50, 95% CI = 0.27–0.91, p = 0.02).
Conclusions |
Patients with atypical HCC have a higher rate of non-hepatitis B or C infections and a lower rate of aggressive tumor biologic behavior. Atypical HCC is an independent predictor of OS.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Large well-differentiated hepatocellular carcinoma (HCC) ≥ 3 cm (defined as atypical HCC) is uncommon. |
• | We found that patients with atypical HCC who underwent resection have a higher rate of non-hepatitis B or C infections. |
• | And a lower rate of aggressive tumor biologic behavior (i.e. a higher proportion of such patients have normal AFP and pathology T1). |
• | Furthermore, atypical HCC is an independent predictor of better overall survival. |
Keywords : Hepatocellular carcinoma, Liver resection, Tumor differentiation
Plan
Vol 223 - N° 2
P. 339-345 - février 2022 Retour au numéro
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