Surgical resection of gastric gastrointestinal stromal tumors (GIST) in octogenarians - 10/02/22
Abstract |
Background |
Localized gastrointestinal stromal tumors (GISTs) are rare tumors typically managed with surgery, but outcomes among octogenarians remain less studied.
Methods |
Octogenarian patients with stage I-III gastric GISTs were identified from the National Cancer Database and classified by resection status. Cox regression and Kaplan-Meier survival analyses analyzed 5-year overall survival (OS). Ninety-day mortality was analyzed following 1:1 propensity score matching.
Results |
Identified octogenarians (N = 949) who underwent resection (N = 632) had improved adjusted OS (71% vs 59.6%, HR 0.75, p 0.049) as compared to non-resected patients. Following matching, 90-day mortality was 5.7% and 11% in resected and non-resected patients (p 0.052), respectively. After exclusion of patients with 90-day mortality, resected patients maintained an OS advantage (77.3% vs 71.1%, HR 0.64, p 0.028).
Conclusions |
The majority of octogenarians with localized gastric GIST are treated with surgery portending improved survival but an appreciable mortality, suggesting a necessity for careful selection of older patients for surgery.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The majority of octogenarians diagnosed with stage I-III gastric GIST undergo surgical resection. |
• | Octogenarians who undergo surgical resection for gastric GIST have improved adjusted overall survival. |
• | Octogenarians who did not undergo surgical resection had insignificantly higher 90-day mortality after diagnosis. |
• | Half of octogenarian patients who were noted to have 90-day mortality expired within the first 30 days after diagnosis. |
• | Careful selection of octogenarian patients with gastric GIST who would benefit from surgical resection is warranted. |
Keywords : GIST, Gastric tumor, Sarcoma, Surgical oncology, Surgical outcomes
Plan
☆ | We have no relevant disclosures. RP DeMatteo is funded by NIH grant CA102613. |
Vol 223 - N° 2
P. 325-330 - février 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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