Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in tuberculosis - 02/02/22

Doi : 10.1016/j.tube.2021.102140

Tuo Liang ^a, Jiarui Chen ^a, GuoYong Xu ^a, Zide Zhang ^a, Jiang Xue ^a, Haopeng Zeng ^a, Jie Jiang ^a, Tianyou Chen ^a, Zhaojie Qin ^a, Hao Li ^a, Zhen Ye ^a, Yunfeng Nie ^b, Chong Liu ^a, Xinli Zhan ^a,^⁎
^a Department of Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, PR China
^b Guangxi Medical University, No.22 Shuangyong Road, Nanning, Guangxi, PR China

^∗Corresponding author. Department of Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, PR China.Department of Spine and Osteopathy WardThe First Affiliated Hospital of Guangxi Medical UniversityNo. 6 Shuangyong RoadNanningGuangxi530021PR China

Abstract

This study was aimed to reveal the role of ferroptosis in tuberculosis infection. To elucidate the ferroptosis-related DEGs, GEO datasets associated with tuberculosis infection were downloaded. The two external validation GEO datasets were exploited for subsequent verification of the ferroptosis-related DEGs. We further evaluated the correlation among the ferroptosis-related DEGs, therapeutic effects, and drug resistance. Finally, we tried to reveal the engagement of the ferroptosis-related DEGs in bone destruction during TB infection. The present study identified SOCS1 as the only ferroptosis-related DEGs. Compared to the non-TB patients, up-regulation of SOCS1 was evident in the TB patients. After receiving standard anti-TB treatment, significant down-regulation of SOCS1 confirmed its acceptance as the marker for therapeutic efficacy. The involvement of SOCS1 has also been suggested in the regulation of the micro immune environment in TB. Furthermore, SOCS1 might play an important role in causing bone destruction during TB infection. FRGs-SOCS1 may be the key gene involved in the pathogenesis and progression of TB infection.

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Keywords : TB, Macrophage polarization, Biomarkers, Bone destruction, Ferroptosis

Abbreviations : GSEA, GO, KEGG, DEGs, TB, EPTB, PTB, XDR-TB, Non-MDR, SOCS1, DS-TB

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Article 102140- janvier 2022 Retour au numéro

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Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in tuberculosis - 02/02/22

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