Cancer protective effects of plums: A systematic review - 16/01/22
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Abstract |
Plums is one of the most cultivated stone fruits due to its fast growing popularity. It has various traditionally recognized health benefits. There are two main commercial types of plums: the European plum (Prunus domestica) and the Japanese plum (Prunus salicina), each having many varieties. Researchers are gathering further evidence of pharmacological effects for plums by scientifically studying its anti-inflammatory, antioxidant properties. A systematic review analysing the literature related to the effects of plums on prevention and treatment of cancer is warranted. This is the first review examining the cancer-related effects of plums. Antioxidation properties of the active constituents of plum were also compared. Scopus, Google Scholar, PubMed, Medxriv and Cochrane Library databases, from their date of inception until July 2021 were utilized. The risk of bias was assessed using CONSORT checklist. A total of 6639 studies were screened and eventually only 54 studies were included. Full-text review of included studies revealed that plum extracts were rich in antioxidants. Overall, most of the studies that fulfilled the eligibility criteria were in vitro and a few clinical studies involving in vivo work. Therefore, it would be beneficial to perform more studies on animals or humans, to confirm that the result obtained from these in vitro studies are able to be extrapolated in a wider range of applications. Further clinical and in vivo studies are warranted to validate plums as a functional food for treatment and prevention of cancer.
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Highlights |
• | Scavenging radical activity (DPPH or FRAP) and the main effects of the plum to the cancer cell were included in this review. |
• | The plum product used, cancer type targeted, and its effect observed from the study were reviewed. |
• | We included 54 studies: 49 studies were in vitro studies, 3 studies were animal studies, and 2 studies are clinical studies. |
• | Cell viability and proliferation effects by plum extract has been shown to be significantly reduced in colon cancers. |
• | Cervix cancer has been shown to be inhibited by the plum extract, although not as significant as other cancer such as breast cancer or liver cancer. |
Keywords : Plum, Cancer, Review, Prunus domestica, Prunus salicina, Antioxidant
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Vol 146
Article 112568- février 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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