Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement - 16/01/22
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Abstract |
Cancer retains a central place in fatality rates among the wide variety of diseases known world over, and the conventional synthetic medicaments, albeit used until now, produce numerous side effects. As a result, newer, better, and safer alternatives such as natural plant products, are gravely required. Essential oils (EOs) offer a plethora of bioactivities including antibacterial, antiviral, antioxidant, and anticancer properties, therefore, the use of EOs in combination with synthetic drugs or aromatherapy continues to be popular in many settings. In view of the paramount importance of EOs and their potential bioactivities, this review summarizes the current knowledge on the interconnection between EOs and cancer treatment. In particular, the current review presents an updated summary of the chemical composition of EOs, their current applications in cancer treatments based on clinical studies, and the mechanism of action against the cancer cell lines. Similarly, an overview of using EOs in aromatherapy and enhancing immunity during cancer treatment is provided. Further, this review focuses on the recent technological advancements such as the loading of EOs using protein microspheres, ligands, or nanoemulsions/nanoencapsulation, which offer multiple benefits in cancer treatment via site-specific and target-oriented delivery of drugs. The continuing clinical studies of EOs implicate that their pharmacological applications are a rewarding research area.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Essential oils (EOs) exhibit anticancer properties in different tumour cell lines. |
• | EOs enhance antioxidant/anti-mutagenic/anti-proliferative activity on cancer cells. |
• | EOs in aromatherapy suppress cancer-associated pain and strengthen immune system. |
• | Nanoemulsions/nanoencapsulation of EOs can guide target-oriented drug delivery. |
• | Newer drug formulations with EOs can help to overcome anticancer drug resistance. |
Keywords : Essential oils, Anticancer activity, Anti-mutagenic activity, Anti-proliferative activity, Aromatherapy, Drug delivery systems
Plan
Vol 146
Article 112514- février 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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