Influence of Histologic Types and Subtypes on Survival Outcomes of Intermediate-High and High-Risk Renal Cell Carcinoma Following Nephrectomy: Findings From the SEER Database - 10/01/22
, Adeniyi Togun b, Isaac Oyejinmi c, Adetunji Bakare d, Oluwakayode Adejoro eAbstract |
Objective |
To understand the influence of histologic subtypes on the survival outcomes of intermediate-high and high-risk renal cell carcinoma (RCC) following nephrectomy.
Methods |
This study employed data files from the SEER Program to identify patients diagnosed with intermediate-high or high risk RCC and treated with nephrectomy. Unadjusted Kaplan Meier curves, and multivariable Cox regression analyses were applied to estimate the hazards of histologic types for overall survival (OS) and cancer-specific survival (CSS).
Results |
OS was higher for chromophobe (HR=0.58, 95% CI 0.47-0.70; P<.0001), similar for papillary (HR=0.90, 95% CI 0.80-1.02; P=.11) and worse for sarcomatoid (HR=3.17, 95% CI 2.70-3.72; P<.0001) subtypes relative to the clear cell subtype. OS was lower in the high-risk disease (HR=2.35, 95% CI 2.01-2.74; P <.0001) versus intermediate-high risk disease. CSS was higher for chromophobe (HR=0.47, 95% CI 0.35-0.63; P<.0001), similar for papillary (HR=0.91, 95% CI 0.77-1.08; P=.28) and worse for sarcomatoid (HR=4.19, 95% CI 3.50-5.02; P<.0001) subtypes relative to the clear cell subtype. CSS was lower for the high-risk disease (HR=2.86, 95%CI 2.39-3.43; P <.0001) relative to intermediate-high risk disease.
Le texte complet de cet article est disponible en PDF.Plan
| Disclosure: This information will be kept confidential. The Editor will discuss the method of disclosure of any potential conflict of interest with the corresponding author on an individual basis. |
Vol 159
P. 146-151 - janvier 2022 Retour au numéro
Article précédent
- Parenchymal Volume Replacement by Renal Cell Carcinoma Prior to Intervention: Predictive Factors and Functional Implications
- Diego Aguilar Palacios, Rebecca A. Campbell, Yosuke Yasuda, Gustavo Roversia, Carlos Munoz-Lopez, Emily Abramczyk, Maureen Kelly, Elvis R. Caraballo, Chalairat Suk-Ouichai, Lin Lin, Chris Weight, Robert Abouassaly, Steven C. Campbell
- Endoscopic Management of Low-Grade Upper Tract Urothelial Carcinoma: Characterizing the Long-term Burden of Care in Comparison to Radical Nephroureterectomy
- Chen Shenhar, Yotam Veredgorn, Shir Bulis, Tzach Aviv, Abd Elhalim Darawsha, Ron Gilad, Jack Baniel, Yaron Ehrlich, David Lifshitz
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?