Thalamocortical Dysconnectivity In Lifelong Premature Ejaculation: A Functional MRI Study - 10/01/22
, Peng Liu 2, 4, ⁎ , Chuanmin Yin 1, ⁎ Abstract |
Objectives |
To detect seed-based functional connectivity (FC) between various cortical sub-regions and the thalamus in lifelong premature ejaculation (LPE) patients and explore whether specific thalamocortical networks are significantly altered in PE patients compared to healthy controls (HCs)
Methods |
Fifty non-medicated LPE patients and 40 age-matched HCs underwent a resting-state functional MRI. FC was adopted to identify specific thalamocortical connectivity between the thalamus and 6 cortical regions of interest (i.e., the motor cortex/supplementary motor, the prefrontal cortex, the temporal lobe, the posterior parietal cortex, the somatosensory cortex and the occipital lobe). In LPE patients, regression analysis was subsequently conducted to assess relationships of thalamocortical connectivity with the Premature Ejaculation Diagnostic Tool (PEDT) score and the Intravaginal Ejaculatory Latency Time (IELT).
Results |
LPE patients had significantly decreased FC between the motor cortex and bilateral ventral thalamus, between the prefrontal cortex and left dorsomedial thalamus, as well as between the temporal cortex and bilateral ventromedial thalamus. In LPE patients, PEDT score was significantly positively associated with the thalamus-posterior parietal cortex FC, and negatively associated with the thalamus-temporal cortex FC, while IELT was positively associated with the thalamus-temporal cortex and thalamus-motor cortex FC.
Conclusion |
These results enrich the imaging evidence for the understanding of the neurobiological mechanisms and/or consequences of LPE.
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| Disclosure: This study was financially supported by the National Natural Science Foundation of China (Nos. 81771918, 62001370, 61971425), Shaanxi National Science Foundation (No.2020JM-197), China Postdoctoral Science Foundation Grant (No. 2019M650985), Young science and technology stars in Shaanxi Province (No. 2021SR5058), Health research talent project of Xi'an Health Commission (No.2021yb61). The funding sources had no further role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. |
Vol 159
P. 133-138 - janvier 2022 Retour au numéro
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