Antibody response in individuals infected with SARS-CoV-2 early after the first dose of the BNT162b2 mRNA vaccine - 05/01/22
Doi : 10.1016/j.jinf.2021.08.008
Federico Gobbi a 
, Dora Buonfrate a , Ronaldo Silva a , Davide Martini a , Zeno Bisoffi a, b , Chiara Piubelli a , Silvia Riccetti c , Alessandro Sinigaglia c , Luisa Barzon c, d, ⁎
, Dora Buonfrate a , Ronaldo Silva a , Davide Martini a , Zeno Bisoffi a, b , Chiara Piubelli a , Silvia Riccetti c , Alessandro Sinigaglia c , Luisa Barzon c, d, ⁎ a Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy
b Department of Diagnostics and Public Health, University of Verona, Verona, Italy
c Department of Molecular Medicine, University of Padova, Via A. Gabelli 63, Padua 35121, Italy
d Microbiology and Virology Unit, Padova University Hospital, Padua, Italy
⁎Corresponding author at: Department of Molecular Medicine, University of Padova, Via A. Gabelli 63, Padua 35121, Italy.Department of Molecular MedicineUniversity of PadovaVia A. Gabelli 63Padua35121Italy
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Highlights |
• | SARS-CoV-2 infection after the first BNT162b2 dose does not boost antibody response. |
• | A postponed second dose induced antibody titres similar to those in naïve vaccinees. |
• | We advise a second vaccine dose for individuals infected early after the first dose. |
Keywords : BNT162b2 vaccine, Neutralizing antibody, RBD-binding IgG antibody, SARS-CoV-2 infection, Antibody response, mRNA vaccine, Adverse events, Delayed second vaccine dose
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© 2021
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 84 - N° 1
P. 94-118 - janvier 2022 Retour au numéro
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