Clinical features of sporadic hepatitis E virus infection in pregnant women in Shanghai, China - 05/01/22
, Ling Wang a, ⁎ , Lin Wang a, ⁎ , Jianliang Zhang c, ⁎ Summary |
Objectives |
Hepatitis E virus (HEV) infection causes high mortality in pregnant women of developing regions during large outbreaks. The aim of this study was to investigate the clinical features of HEV-infected pregnant women in Shanghai, China where the epidemiology of HEV has shifted from large outbreaks to the sporadic form.
Methods |
Clinical data of 516 pregnant and nonpregnant child-bearing age women diagnosed with HEV infection during 2009–2020 was collected at the Shanghai Public Health Clinical center. Patients’ data were analysed for clinical features and laboratory parameters accordingly.
Results |
Most of the hospitalized HEV-infected pregnant women (85.23%, 127/149) showed no obvious clinical symptoms and the disease outcome was generally benign with no liver failure or maternal mortality observed in the patients. By comparison, fewer (37.21%, 32/86) of the HEV-infected nonpregnant women were asymptomatic, and five cases (5.81%, 5/86) of liver failure were observed among them. The levels of serum alanine aminotransferase, aspartate aminotransferase, total bilirubin (TBiL), direct bilirubin (DBiL) and total bile acids (TBA) were significantly higher (P < 0.05) in nonpregnant women than those of the pregnant women. We found 42.99% (46/107) births had adverse foetal/neonatal outcome. Mothers who presented with adverse foetal/neonatal outcome showed higher (P < 0.05) serum TBiL, DBiL and TBA levels than those without.
Conclusion |
We found that the clinical features of sporadic HEV infection in pregnant women in Shanghai, China are generally mild and no maternal mortality occurred. However foetal/neonatal adverse outcomes including preterm births and stillbirths were observed in HEV-infected pregnant women.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Clinical features in HEV-infected pregnant women in Shanghai, China are generally mild and no maternal mortality occurs. |
• | In 42.99% of births adverse foetal/neonatal outcomes seen include preterm births and stillbirths. |
• | Anti-HEV IgG may be passed from mother to child. |
• | Universal vaccination of women of child-bearing age should be considered in the future to avoid HEV-associated adverse foetal/neonatal outcomes in pregnant women. |
Keywords : Hepatitis E, Hepatitis E virus, Clinical features, Pregnant women
Abbreviations : HEV, ALT, AST, ALP, GGT, TBil, DBiL, ALB, TBA, INR, PTA
Plan
Vol 84 - N° 1
P. 64-70 - janvier 2022 Retour au numéro
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