Immunocompromised children and young people are at no increased risk of severe COVID-19 - 05/01/22
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Highlights |
• | UK immunocompromised paediatric patients were at no increased risk of severe COVID-19. |
• | Only 4/38 PCR detected infections were admitted to hospital. None had acute severe COVID-19 or died. |
• | Increasing age and immunodeficiency increased reporting of SARS-CoV-2 infection. Worsening of fever, cough and sore throat were associated with reporting SARS-CoV-2 infection. |
• | Serology results suggest there was a proportion of SARS-CoV-2 infections undetected by PCR. |
Abstract |
Objectives |
We aimed to prospectively describe the incidence and clinical spectrum of SARS-CoV-2 infection in immunocompromised paediatric patients in the UK.
Methods |
From March 2020 to 2021 weekly questionnaires were sent to immunocompromised paediatric patients or their parents. Information, including symptom presentation and SARS-CoV-2 PCR test results, was collected from 1527 participants from 46 hospitals. Cross-sectional serology was investigated in February and March 2021.
Results |
Until the end of September 2020, no cases were reported. From September 28th 2020 to March 2021 a total of 38 PCR-detected SARS-CoV-2 infections were reported. Of these, four children were admitted to hospital but none had acute severe COVID-19. Increasing age in association with immunodeficiency increased reporting of SARS-CoV-2 infection. Worsening of fever, cough, and sore throat were associated with participants reporting SARS-CoV-2 infection. Serology data included 452 unvaccinated participants. In those reporting prior positive SARS-CoV-2 PCR, there were detectable antibodies in 9 of 18 (50%). In those with no prior report of infection, antibodies were detected in 32 of 434 (7•4%).
Conclusions |
This study shows SARS-CoV-2 infections have occurred in immunocompromised children and young people with no increased risk of severe disease. No children died.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, COVID-19, Children, Immunocompromised
Plan
Vol 84 - N° 1
P. 31-39 - janvier 2022 Retour au numéro
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