Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy: A novel diagnosis clue - 28/12/21

Résumé |
Introduction |
Hypertrophic cardiomyopathy (HCM) may be associated with very narrow QRS while left ventricular hypertrophy (LVH) may increase QRS duration. We investigated the relationship between QRS duration and LV mass in subtypes of abnormal LV wall thickness.
Methods |
Four groups of patients from Toulouse and Bordeaux University Hospitals were retrospectively included, with HCM, LVNC, LVH and controls with healthy hearts. Automatic measurement of LVM on MRI was correlated to automatic measurement of QRS duration on ECG. Uni- and multivariate analysis were performed between groups including explanatory variables expected to influence LVM and QRS duration. The relationships between QRS duration and LVM was further studied within each group.
Results |
In total, 221 HCM, 28 LVNC, 16 LVH and 40 controls were retrospectively included. Mean QRS duration was 92ms for HCM, 104 for LVNC, 110 for LVH and 92 for controls (P<0.01). Mean LVM was 100, 90, 108 and 68g/m2 respectively (P<0.01). QRS duration, LVM, hypertension, maximal wall thickness and LGE were significantly linked to HCM in multivariate analysis (w/wo bundle branch block). An independent negative correlation was found between LVM and QRS duration in the HCM group, while the relationship was reverse in LVNC, LVH and in controls.
Conclusion |
QRS duration increases with LVM in LVNC, LVH or in healthy hearts while reverse relationship is present in HCM. These relationships were independent of other parameters. These results warrant additional investigations for refining diagnosis criteria for HCM in the future.
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Vol 14 - N° 1
P. 82 - janvier 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.