Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011 - 21/12/21
, Yevgeniya Gokun, MS 3, Paul A. Romitti, PhD 4, Sarah C. Tinker, PhD, MPH 5, April D. Summers, MPH 5, Paula K. Roberson, PhD 3, Charlotte A. Hobbs, MD, PhD 6, Sadia Malik, MD, MPH 7, 8, Lorenzo D. Botto, MD 9, Wendy N. Nembhard, PhD, MPH 10the
National Birth Defects Prevention Study
Abstract |
Objectives |
To assess associations between maternal smoking and congenital heart defects (CHDs) in offspring.
Study design |
We performed a retrospective case-control study using data for cases of CHD (n = 8339) and nonmalformed controls (n = 11 020) from all years (1997-2011) of the National Birth Defects Prevention Study. Maternal self-reported smoking 1 month before through 3 months after conception was evaluated as a binary (none, any) and categorical (light, medium, heavy) exposure. Multivariable logistic regression was used to estimate aOR and 95% CIs. Stratified analyses were performed for septal defects according to maternal age, prepregnancy body mass index, and maternal race/ethnicity.
Results |
Multiple CHDs displayed modest associations with any level of maternal periconceptional smoking independent of potential confounders; the strongest associations were for aggregated septal defects (OR, 1.5; 95% CI, 1.3-1.7), tricuspid atresia (OR, 1.7; 95% CI, 1.0-2.7), and double outlet right ventricle (DORV) (OR, 1.5; 95% CI, 1.1-2.1). Tricuspid atresia and DORV also displayed dose-response relationships. Among heavy smokers, the highest odds were again observed for tricuspid atresia (aOR 3.0; 95% CI, 1.5-6.1) and DORV (aOR 1.5; 95% CI, 1.1-2.2). Heavy smokers ≥35 years old more frequently had a child with a septal defect when compared with similarly aged nonsmokers (aOR 2.3; 95% CI, 1.4-3.9).
Conclusions |
Maternal periconceptional smoking is most strongly associated with septal defects, tricuspid atresia, and DORV; the risk for septal defects is modified by maternal age.
Le texte complet de cet article est disponible en PDF.Keywords : tobacco, pregnancy, congenital heart disease
Abbreviations : ASD, AVSD, CHD, DORV, NBDPS, VSD
Plan
| Supported through Centers for Disease Control and Prevention (CDC) cooperative agreements under PA #96043, PA #02081, and FOA #DD09-001, FOA #DD13-003, and NOFO #DD18-001 to the Centers for Birth Defects Research and Prevention participating in the NBDPS and/or the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS); the National Institute of Child Health and Human Development (1R03HD050663-01A1); the National Center on Birth Defects and Developmental Disabilities (NCBDDD) (5U01DD000491-05); and a grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (#5R01HD039054-12). The CDC reviewed the manuscript. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. The authors declare no conflicts of interest. |
Vol 240
P. 79 - janvier 2022 Retour au numéro
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