The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice - 21/12/21
Doi : 10.1016/j.jpeds.2021.09.033
Stephanie J. Wu, MD 1, Jeanne A. Darbinian, MS, MPH 2, Jeffrey B. Schwimmer, MD 3, 4, Elizabeth L. Yu, MD 3, 4, Nirmala D. Ramalingam, MPP 1, Louise C. Greenspan, MD 5, 6, Joan C. Lo, MD 2, 6
1 Department of Medicine, Kaiser Permanente Oakland Medical Center, Oakland, CA
2 Division of Research, Kaiser Permanente Northern California, Oakland, CA
3 Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, CA
4 Department of Gastroenterology, Rady Children's Hospital, San Diego, CA
5 Kaiser Permanente San Francisco Medical Center, San Francisco, CA
6 The Permanente Medical Group, Oakland, CA
Abstract |
Using a clinically actionable threshold for alanine aminotransferase to define suspected nonalcoholic fatty liver disease in US children with obesity, the risk of suspected nonalcoholic fatty liver disease was highest for Asian and Hispanic race/ethnicity, male sex, and severe obesity.
Le texte complet de cet article est disponible en PDF.Keywords : nonalcoholic fatty liver disease, NAFLD, obesity, children, race, ethnicity, alanine aminotransferase, ALT
Abbreviations : ALT, BMI, NAFLD
Plan
| Funded by Graduate Medical Education Research with support from the Kaiser Permanente Community Benefit Program. J.S. and S.W. are supported by the National Institutes of Health, United States (UL1TR001442). The content is solely the responsibility of the authors and does not necessarily represent the official views of Kaiser Permanente Northern California, United States, The Permanente Medical Group, or the National Institutes of Health, United States. J.S. reports grants to the University of California, San Diego, United States from Intercept and Seraphina. N.R. owns stock valued at <$20 000 in AbbVie, Inc. and previously owned stock in Takeda and Amgen. The other authors declare no conflicts of interest. |
© 2021
Elsevier Inc. Tous droits réservés.
Vol 240
P. 280-283 - janvier 2022 Retour au numéro
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