Randomized Pilot Trial on Optimal Treatment Strategy, Myocardial Changes, and Prognosis of Patients with Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA) - 15/12/21
, Petras Navickas, MD a, Mindaugas Lizaitis, MD a, Sigita Glaveckaite, MD, PhD a, Kestutis Rucinskas, MD, PhD a, Zaneta Petrulioniene, MD, PhD a, Nomeda Valeviciene, MD, PhD a, Robertas Stasys Samalavicius, MD a, Andrius Berukstis, MD, PhD a, Arvydas Baranauskas, MD, PhD a, Urte Gargalskaite, MD a, Aleksandras Laucevicius, MD, PhD a, Qin M. Chen, MD, PhD b, Joseph S. Alpert, MD, PhD b, Pranas Serpytis, MD, PhD aAbstract |
Background |
Myocardial infarction with nonobstructive coronary arteries (MINOCA) remains an unresolved challenge. Many different diagnostic approaches are often required to diagnose, confirm, and evaluate MINOCA. The prevalence can be as high as 13% of all acute myocardial infarction patients, indicating that this condition is not rare. At this time, there have been no completed randomized clinical trials involving MINOCA patients, and a better understanding of the mechanisms and management of these patients is important. This exploratory analysis seeks to find possible etiologic factors, the value of novel biomarkers, and the effect of different treatment strategies in patients with MINOCA.
Methods |
This prospective randomized pilot trial will include 150 patients with MINOCA. A thorough clinical, laboratory, and imaging evaluation will be performed, including novel biomarkers and modern imaging techniques (heart magnetic resonance imaging and noninvasive testing). The duration of the enrollment is 18 months, and duration of the follow-up is 12 months from the enrollment of the first patient.
Results |
The trial is registered under www.clinicaltrials.gov: NCT04538924. The study is currently recruiting participants.
Conclusions |
Because MINOCA is not a benign disease, the results of the current investigation could inform future diagnostic and therapeutic strategies and enhance the understanding of MINOCA patients.
Le texte complet de cet article est disponible en PDF.Keywords : MINOCA, Myocardial infarction, Myocardial infarction with nonobstructive coronary arteries
Plan
| Funding: This study has received funding from the European Social Fund (project No 09.3.3-LMT-K-712-0148) under a grant agreement with Research Council of Lithuania (LMTLT). |
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| Conflicts of Interest: None. |
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| Authorship: All authors participated in the study. RS: Conceptualization, project administration, investigation, data curation; EM: Writing—original draft, investigation, data curation; PN: Investigation, data curation, writing—original draft; ML: Investigation, data curation, writing—original draft; SG: Supervision, project administration; KR: Supervision, project administration; ZP: Conceptualization, project administration; NV: Conceptualization, project administration; RSS: Conceptualization; A. Berukstis: Investigation, project administration; A. Baranauskas: Investigation, project administration; UG: Investigation, data curation; AL: Supervision; QMC: Conceptualization, supervision, writing—review & editing; JSA: Conceptualization, supervision, writing—review & editing; PS: Conceptualization, supervision, writing—review & editing. |
Vol 135 - N° 1
P. 103-109 - janvier 2022 Retour au numéro
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