The role of aquaporin 4 (AQP4) in spinal cord injury - 12/12/21
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Abstract |
Aquaporin-4 (AQP-4) is an aquaporin composed of six helical transmembrane domains and two highly conserved ASN-pro-ALA (NPA) motifs. It is strongly expressed in rodent and human spinal cord tissues and plays a key role in the pathological process after SCI. After SCI, edema, glial scarring, and inflammation can accelerate the progression of injury and lead to deterioration of function. Many studies have reported that AQP-4 plays an important role in SCI. In particular, it plays an important role in secondary pathological processes (spinal cord edema, glial scar formation, and inflammatory response) after SCI. Loss of AQP-4 has been associated with reduced spinal edema and improved prognosis after SCI in mice. In addition, downregulation of AQP-4 reduces glial scar formation and the inflammatory response after SCI. There is a consensus from numerous studies that AQP-4 may be a potential target for SCI therapy, which guides the ongoing investigation for molecular therapy of SCI. Here, we review the structure of AQP-4, its expression in normal and damaged spinal cord, and its role in SCI, as well as discuss the theoretical basis for the treatment of SCI.
Le texte complet de cet article est disponible en PDF.Highlights |
• | This paper reviews the recent literature on AQP4 and spinal cord injury. |
• | According to the role of AQP4 in spinal cord injury, the role of AQP4on spinal cord injury field was summarized. |
• | It is concluded that AQP4 may be a potential therapeutic target for spinal cord injury. |
• | This review is valuable to all who are engaged in this field. |
Keywords : Wnt signaling, AQP-4, Spinal cord injury (SCI), Therapeutic target, Axon regeneration
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Vol 145
Article 112384- janvier 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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