Stress hormones kinetics in ventricular fibrillation cardiac arrest and resuscitation: Translational and therapeutic implications - 30/11/21
, Themis Gkraikou b, Gavino Faa c, Dimitrios Barouxis d, Evangelia Kesidou e, Theodoros Mavridis f, Athanasios Chalkias g, 1, Theodoros Xanthos b, 1Abstract |
Background |
Knowing the kinetics of endogenous stress hormones during cardiac arrest and cardiopulmonary resuscitation (CRP) will help to optimize personalized physiology-guided treatment. The aim of this study was to examine the dynamic changes in stress hormones in a swine model of ventricular fibrillation (VF) cardiac arrest.
Methods |
Ventricular fibrillation was induced in 10 healthy Landrace/Large White piglets, which were subsequently left untreated for 8 min. All animals were resuscitated according to the 2015 European Resuscitation Council guidelines. The concentration of adrenalin, noradrenalin, and cortisol was measured at baseline and at the 4th and 8th minute of VF-cardiac arrest, as well as at 30-min, 60-min, 24 h and 48 h post-ROSC.
Results |
By the end of the 4th min of VF, the animals of the ROSC group exhibited significantly higher adrenaline levels compared to those of the no-ROSC group (7264 pg/ml vs. 1648 pg/ml, p = 0.03). Noradrenaline was higher in the ROSC group at the 4th min of VF (3021 pg/ml vs. 1626 pg/ml, p = 0.02). Cortisol levels in the ROSC group were significantly lower by the end of the 8th min of VF [16.25 ng/ml vs. 92.82 ng/ml, p = 0.03]. With a cut-off point of 5970 pg/ml, adrenaline at the 4th min of VF exhibited 100% sensitivity and 80% specificity for predicting ROSC.
Conclusion |
Higher endogenous adrenaline and lower endogenous cortisol levels were associated with ROSC.
Le texte complet de cet article est disponible en PDF.Highlights |
• | ROSC animals had significantly higher catecholamine levels compared to the no-ROSC at the end of the 4th minute of CA. |
• | Cortisol levels were lower in the ROSC group at the end of the 8th min of VF. |
• | Catecholamines (4th min of VF) and cortisol (8th min of VF) exhibited 100% sensitivity, 80% specificity in predicting ROSC. |
Keywords : Stress hormones, Resuscitation, ROSC, Ventricular fibrillation, Cardiac arrest
Plan
Vol 50
P. 14-21 - décembre 2021 Retour au numéro
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