Lower trabecular bone score in type 2 diabetes mellitus: A role for fat mass and insulin resistance beyond hyperglycaemia - 30/11/21
, María Dolores Avilés-Pérez a, b, c, Sheila González-Salvatierra a, b, d, Francisco Andújar-Vera b, Enrique Moratalla-Aranda b, e, Manuel Muñoz-Torres a, b, c, d
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Abstract |
Aims |
To examine the clinical and biochemical determinants of trabecular bone score (TBS) in type 2 diabetes mellitus (T2DM) patients.
Methods |
Cross-sectional observational study in 137 T2DM patients (49–85 years). Whole-body fat percentage was estimated using the relative fat mass (RFM) equation. Bone mineral density (BMD) and TBS were assessed using dual-energy X-ray absorptiometry and TBS iNsight Software respectively.
Results |
T2DM patients showed significantly lower TBS values (P < 0.001) despite significantly higher lumbar spine BMD (LS-BMD) (P = 0.025) compared to controls. TBS values were negatively correlated with body mass index (BMI) (P < 0.001), waist circumference (P < 0.001), and HOMA-2IR index (P = 0.004) and positively correlated with sex hormone-binding globulin (SHBG) (P = 0.01) and LS-BMD (P = 0.003). RFM was negatively associated with TBS in both males (P < 0.001) and females (P = 0.005). The multivariate analysis showed that RFM, HOMA2-IR (negative), SHBG, and LS-BMD (positive) were the variables independently associated with TBS. ROC analysis revealed RFM as the variable with the highest predictive value for risk of degraded bone microarchitecture.
Conclusions |
The adiposity estimated by RFM may negatively affect TBS and this relationship may be influenced by insulin resistance and SHBG. RFM could act as a key estimator of degraded bone microarchitecture risk in the T2DM population.
Le texte complet de cet article est disponible en PDF.Keywords : Relative fat mass, SHBG, Trabecular bone score, Type 2 diabetes mellitus
Plan
| Person to whom reprint requests should be addressed: Dr. Manuel Muñoz Torres Bone Metabolic Unit, Endocrinology and Nutrition Division. Hospital Universitario San Cecilio. Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA). Av. de la Ilustración, s/n, 18016, Granada, Spain. |
Vol 47 - N° 6
Article 101276- novembre 2021 Retour au numéro
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