The relationship between visceral adiposity and cardiometabolic risk in Chinese women with polycystic ovary syndrome - 25/11/21

Doi : 10.1016/j.orcp.2021.09.004

N.Y.H. Ng ^a, K.H. Liu ^b, C.H.T. Tam ^a, G. Jiang ^a, F. Cheng ^a, Y. Hou ^a, T.T. Yau ^a, R. Ozaki ^a, M.H. Chan ^c, C.K. Lim ^a, D.S. Sahota ^d, T.C. Li ^d, L.P. Cheung ^d, W.H. Tam ^d, W.C.W. Chu ^b, R.C.W. Ma ^a,^e,^f,⁎
^a Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
^b Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China
^c Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
^d Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
^e Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
^f Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China

^⁎Corresponding author at: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.Department of Medicine and TherapeuticsThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina

Abstract

Objective

To compare the extent to which visceral adiposity, as measured by mesenteric fat thickness, contribute to cardiometabolic risk, especially insulin resistance, in women with PCOS and healthy control.

Methods

This is a cross-sectional study with a total of 190 women with PCOS fulfilling the Rotterdam diagnostic criteria. Women without PCOS were recruited from a previous study, which comprised 416 healthy women controls with normal glucose tolerance. All subjects underwent OGTT, biochemical assessment, and sonographic assessment with measurements of mesenteric, preperitoneal and subcutaneous fat thickness.

Results

Mesenteric fat thickness was strongly correlated to cardiometabolic traits including blood pressure, fasting and 2-h glucose, triglycerides, HOMA-IR; and was negatively correlated to HDL-C in both cohorts (all p < 0.01). In PCOS, positive correlation was observed between mesenteric fat thickness and free androgen index (p < 0.01). Compared with controls, the regression line between mesenteric fat and HOMA-IR is much steeper in PCOS (p < 0.01).

Conclusion

Women with PCOS remain more insulin resistant compared to controls at any given degree of visceral adiposity.

Le texte complet de cet article est disponible en PDF.

Keywords : Adiposity, Visceral fat, PCOS, Insulin resistance

Plan

Introduction

Subjects, materials and methods

Subjects

Clinical, anthropometrical, and biochemical parameters

Laboratory analyses

Main outcome measures

Sonographic examinations

Statistical analyses

Results

Comparison of clinical characteristics of women with PCOS and healthy controls

Abdominal adiposity in women with PCOS and healthy controls

Visceral adiposity and metabolic parameters in PCOS vs healthy controls

Independent predictors of insulin resistance, as measured as HOMA-IR, in women with PCOS only

Discussion

Funding

Disclosure

Declaration of interests

CRediT authorship contribution statement

Export

Vol 15 - N° 6

P. 593-599 - novembre 2021 Retour au numéro

Article précédent

Relationship between obesity and school absenteeism in Australian children: Implications for carer productivity
Joseph Carrello, Thomas Lung, Anagha Killedar, Louise A. Baur, Alison Hayes

| Article suivant

Early-onset severe obesity due to homozygous p.R105W (c313C> T) mutation in leptin gene in Turkish siblings: Two cases reports
Sevde Nur F?rat, Hüseyin Onay

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

The relationship between visceral adiposity and cardiometabolic risk in Chinese women with polycystic ovary syndrome - 25/11/21

Abstract

Objective

Methods

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL