Hypoxia regulation of facilitated glucose transporter-1 and glucose transporter-3 in mouse chondrocytes mediated by HIF-1α - 19/04/08
, Jun Wang, Ya-Ping Zhu, Li Wei, Qi Zhou
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Abstract |
Objectives |
Chondrocytes reside in a hypoxic environment; they utilize glucose as the main energy source. Facilitated glucose transport represents the first rate-limiting step in glucose metabolism.
Results |
Here we demonstrated that hypoxia induced an elevated expression level of GLUT-1 and -3 in chondrocytes. Also elevated was hypoxia inducible factor-1
(HIF-1) protein level. On the contrary, deletion of HIF-1 led to complete loss of the hypoxia-induced gene expression of GLUT-1 and 3.
Conclusion |
These results suggested that chondrocytes had the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes, and that hypoxia regulation of facilitated GLUT-1 and -3 was mediated by HIF-1.
Keywords : Chondrocyte, Glucose transporter, Hypoxia, Hypoxia inducible factor-1
Plan
Vol 75 - N° 2
P. 176-181 - mars 2008 Retour au numéro
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