Oncocytic Papillary Renal Cell Carcinoma in an 11-year-old girl - 30/10/21
Doi : 10.1016/j.urology.2021.04.009
Akl Bernard 1, Jabbour Teddy 1, Haydar Asad 2, Bedoyan Zarouhie 3, Ghandour Fatme 3, Jabbour Michel 1, ⁎ 
1 Department of Urology, University of Balamand, Saint George Hospital University Medical Center, Beirut, Lebanon
2 University of Balamand, Faculty of Medicine and Medical Sciences, Beirut, Lebanon
3 Department of Pathology, University of Balamand, Saint George Hospital University Medical Center, Beirut, Lebanon
⁎Address correspondence to: Jabbour Michel, M.D. FAES MBA, Department of Urology, University of Balamand, Beirut, Lebanon.Department of UrologyUniversity of Balamand,BeirutLebanon
Abstract |
Oncocytic Papillary Renal Cell Carcinoma (OPRCC) is a rare variant of renal cell carcinoma with overlapping characteristics type 1 and 2 of papillary renal carcinoma. Based on the literature, OPRCC is predominantly present in adult males. OPRCC has a specific genetic affiliation with the Fumarate Hydratase gene requiring all patients diagnosed with OPRCC to undergo genetic testing. There isn't any agreement for the treatment of OPRCC due to the rarity of the disease; however, a radical nephrectomy poses as a possible modality. Therefore, we present the rare case of an 11-year-old female found to have OPRCC.
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| Disclosures: The authors of this commentary have no financial disclosures. |
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| Declaration of interest: There are no conflicts of interest to declare. |
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| Eric Klein, MD, Editor-in-Chief, UROLOGY, Glickman Urologic and Kidney Institute, Q10, 9500 Euclid Ave, Cleveland, OH 44195, Phone: 216-445-6664/216-445-9738 (Editorial Office), Fax: 216-636-5104, E-mail: goldjournal@ccf.org |
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| Dear Dr. Klein, We are submitting our manuscript entitled “Oncocytic Papillary Renal Cell Carcinoma in an 11-year-old girl” as a pediatric urology case report for consideration of publication in The Gold Journal. We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper, we report a case of an 11-year-old female presenting with a rare pathology of renal cell carcinoma. To the best of our knowledge, this is the only reported case of an oncocytic papillary renal cell carcinoma in a such a demographic. We are depicting a rare pathologic variant in an unprecedented age demographic. Given the paucity of literature concerning this subject, we aim to highlight the aforementioned pathology as a means to elaborate the intertwined genetic nature of renal cell carcinoma. In the era of genetic advancements and testing, such rare variants presenting at a young age should encourage renal cell carcinoma genetic testing in an effort to reveal potential risk factors and guide future treatment options. |
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| We have no conflicts of interest to disclose Please address all correspondence concerning this manuscript to myself at drmjabbour@gmail.com Mobile: +96170668209 Address: Saint George Hospital P.O.Box 166 378 Achrafieh Beirut 11 00 2807 We appreciate your time in handling our manuscript and hope you will find our manuscript compelling to be published in The Gold Journal. |
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| Regards, Michel Jabbour, M.D. Professor of Urology, University of Balamand Chairman of Surgery, SGHUMC, Beirut |
© 2021
Elsevier Inc. Tous droits réservés.
Vol 156
P. e134-e136 - octobre 2021 Retour au numéro
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