Real World Data of Penile Cancer Treatment at a High-Volume Center in South America: Insights and Survival Trends - 30/10/21
, Julián Pardo 1, Daniel Suso-Palau 2, Luis Becerra 1, Diego Camacho 1, Fabián Godoy 1, Jorge Forero 1, Marino Cabrera 1, Byron López-de-Mesa 1, Angie Ramirez 1, Rodolfo Varela 1ABSTRACT |
Objective |
To report survival trends and oncological outcomes of penile cancer surgically treated patients, at a high-volume center, treating more than 25 patients each year, in a high incidence country.
Methods |
Clinical charts of all patients that underwent surgical management for penile cancer were reviewed. The primary end points were cancer specific survival (CSS), progression-free survival, and local recurrence free survival. Kaplan-Meier plots were used for survival analyses. Multivariate analysis was performed using cox proportional hazard age-adjusted models to determine the effect of pN, pT, lymphovascular invasion for CSS.
Results |
A total of 209 patients were identified, with a median follow up of 96 months (IQR 49-133). Organ-sparing surgerywas performed in 72.7%, 56.9% underwent dynamic sentinel lymph node biopsy, 110 patients underwent inguinal lymph node dissection, and 45 (21.5%) pelvic lymph node dissection. A total of 75 (35.8%) of patients relapsed, median time to relapse of 12 months (IQR 6-25). Overall estimates of CSS showed an 8-year CSS of 68.9%. Eight-year CSS was 90.5% for N0, and 32.8% in pN3 (P <.001). The Cox proportional hazard model showed that pN1-3, pT2-4, lymphovascular invasion and positive dynamic sentinel lymph node biopsy were the variables associated with worse 8-year CSS.
Conclusion |
To the best of our knowledge, we report one of the largest cohorts on the survival outcomes of penile cancer surgical treatment, in a single institution, over a long period of time, were most patients are referred with high-risk, locally advanced or nodal disease.
Le texte complet de cet article est disponible en PDF.Plan
| Financial Disclosure: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. |
|
| Funding Support: Authors have no funding sources to report. |
|
| Ethics Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Medical University of Instituto Nacional de Cancerologia. |
|
| Consent to Participate: Informed consent was obtained from all individual participants included in the study. |
Vol 156
P. 199-204 - octobre 2021 Retour au numéro
Article précédent
- AUTHOR REPLY
- Joshua M. Kuperus, Brian R. Lane
- Impact of Plant-Based Diet on PSA Level: Data From the National Health and Nutrition Examination Survey
- Ali Mouzannar, Manish Kuchakulla, Ruben Blachman-Braun, Sirpi Nackeeran, Maria Becerra, Bruno Nahar, Sanoj Punnen, Chad Ritch, Dipen J. Parekh, Mark L. Gonzalgo
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?