Adjunctive corticosteroid treatment for organizing pneumonia in COVID-19 patients with persistent respiratory failure - 19/10/21

Doi : 10.1016/j.rmed.2021.106571

Francesco Vladimiro Segala ^⁎
Infectious Diseases Unit, Catholic University of the Sacred Heart, Rome, Italy

^∗Corresponding author. Infectious Diseases Unit, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168, Rome, Italy.Infectious Diseases UnitCatholic University of the Sacred HeartLargo Francesco Vito 1Rome00168Italy
Giacomo Sgalla
Unità Operativa Complessa di Pneumologia, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy

Federica Salvati
Infectious Diseases Unit, Catholic University of the Sacred Heart, Rome, Italy

Ludovica Berardini
Unità Operativa Complessa di Pneumologia, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy

Marcantonio Negri, Elisabetta Nardella, Annalisa Potenza
Istituto di Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

Rita Murri, Massimo Fantoni
Division of Infectious Diseases, Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

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Abstract

Since the beginning of COVID-19 pandemic, clinical, radiological and histopathological features consistent with viral-induced organizing pneumonia (OP) have been reported as hallmark characteristics of the disease. Here, we describe the case of ten patients with severe COVID-19 pneumonia treated with methylprednisolone 1mg/kg for showing clinical and radiological features suggestive of OP at least 20 days after symptom onset and despite standard treatment for COVID-19.

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Keywords : Corticosteroids. COVID-19. organizing pneumonia