Patterns of quadruple therapy use including bismuth for Helicobacter pylori eradication: A cohort study in the French national claims database - 15/10/21
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Summary |
Background |
Quadruple therapy using a single capsule formulation of bismuth, metronidazole and tetracycline (BMT; Pylera®), associated with omeprazole for the eradication of Helicobacter pylori, represents the reintroduction of bismuth in France after 40 years.
Objective |
To describe the real-life patterns of use of BMT following a request from the French health authorities.
Methods |
Patients with a first BMT dispensing (index date, ID), with one year of data before and after ID, were identified in the French nationwide claims database 1/97 sample. Misuse of BMT was defined as dispensing>1 pack of BMT at ID or absence of a diagnostic test in the preceding year.
Results |
In total, 540 patients were included. Prescribers were gastroenterologists (n=243; 45%) and general practitioners (n=160; 30%). A proton pump inhibitor was co-dispensed to 504 patients (96%). Ten patients (2%) had contraindications to BMT. Fifty-nine patients (11%) met the misuse criteria: ten (2%) were dispensed>1 pack of BMT and 49 (9%) had not had a diagnostic test for H. pylori in the previous year. During follow-up, 27 patients (5%) required retreatment (treatment failure).
Conclusion |
In this real-life study, most patients were dispensed only one pack of BMT, consistent with recommendations. Misuse related principally to the absence of prior diagnostic test for H. pylori.
Le texte complet de cet article est disponible en PDF.Keywords : Helicobacter pylori, Bismuth, Metronidazole, Tetracycline, France, Misuse, Pharmacoepidemiology
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Vol 76 - N° 5
P. 435-440 - septembre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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