Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance - 09/10/21
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Abstract |
Cardiac fibrosis can lead to heart failure, arrhythmia, and sudden cardiac death, representing one of the leading causes of death due to cardiovascular diseases. Cardiac fibrosis involves several multifactorial processes that cannot be effectively controlled by the available therapies. Therefore, current research has focused on the development of novel drugs that can be used to prevent cardiac fibrosis. Recent studies on the functions of inflammasome have provided an in-depth understanding of the regulatory functions of inflammasome in cardiac fibrosis. This review summarizes the latest research on the functions of the NLRP3 inflammasome in various cardiovascular diseases. The latest findings indicate that the NLRP3 inflammasome mediates several inflammatory responses and is associated with pyroptosis, mitochondrial regulation, and myofibroblast differentiation in cardiac fibrosis. These novel findings provide insight into the vital role of the NLRP3 inflammasome in the pathogenesis of cardiac fibrosis, which can be used to identify new targets for its prevention and treatment.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Cardiac fibrosis is one of the leading causes of death due to CVDs. |
• | NLRP3 inflammasome played important functions in the process of cardiac fibrosis. |
• | Potential therapeutic approaches targeting NLRP3 inflammasome for CVDs. |
Keywords : NLRP3 inflammasome, cardiac fibrosis, inflammation, pyroptosis, mitochondrial regulation, myofibroblast differentiation, other inflammasomes
Plan
Vol 143
Article 112219- novembre 2021 Retour au numéro
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