Bloodstream Infections in Preterm Neonates and Mortality-Associated Risk Factors - 22/09/21
Abstract |
Objective |
To investigate the association of early (±4 hours after onset of bloodstream infection) clinical and laboratory variables with episode-related mortality (<7 days).
Study design |
This 2-site retrospective study included 142 neonates born at <35 weeks of gestational age with positive blood/cerebrospinal fluid (CSF) culture at >72 hours of age from organisms other than coagulase-negative Staphylococcus. Early variables were compared between those with bloodstream infection-related mortality and survivors. Multivariable analysis was conducted for the primary outcome, and the area under the curve (AUC) was estimated for relevant variables.
Results |
The neonates who died were of lower gestational age at disease onset. After adjusting for relevant variables, lowest mean blood pressure (MBP) (aOR, 0.10; 95% CI, 1.02-1.19) and highest base deficit (aOR, 1.18; 95% CI, 1.06-1.32) were independently associated with mortality. The AUC was 0.87 (95% CI, 0.78-0.96) for base deficit, increasing to 0.91 (95% CI, 0.83-0.99) with the addition of MBP.
Conclusion |
Low MBP and high base deficit within ±4 hours of bloodstream infection onset identify preterm neonates at risk of mortality.
Le texte complet de cet article est disponible en PDF.Keywords : nosocomial infection
Abbreviations : AUC, CoNS, CSF, FiO2, MAP, MBP, NEC, NICU, nSOFA, SpO2, VLBW
Plan
| The authors declare no conflicts of interest. |
Vol 237
P. 206 - octobre 2021 Retour au numéro
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