Cross reactivity of serological response to SARS-CoV-2 vaccination with viral variants of concern detected by lateral flow immunoassays - 21/09/21
Doi : 10.1016/j.jinf.2021.07.020
Daniel Ebanks a, Sian Faustini a, Adrian Shields b, Helen Parry b, Paul Moss b, Tim Plant a, Alex Richter b, Mark Drayson b, ⁎ 
a Clinical Immunology Service, Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom
b Institute of Immunology and Immunotherapy, University of Birmingham and Birmingham Health Partners, University Hospitals NHS Foundation Trust, Birmingham, United Kingdom
⁎Corresponding author.
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Highlights |
• | IgG anti-SARS-CoV-2 spike glycoprotein antibody levels were greatest after vaccination and lowest after natural non-hospitalised infection. |
• | Using lateral flow tests incorporating wildtype (Wuhan) spike glycoprotein, 40 serum samples post second vaccine dose were positive. |
• | Changing the spike glycoprotein in the lateral flow tests to that from Alpha or Beta or Gamma variants of concern resulted for all three variants, in 40/40 positive results albeit at lower levels. |
• | Changing the spike glycoprotein in the lateral flow tests to that from the Delta variant of concern (VOC) resulted in 37/40 positive results. |
• | The WHO standard NIBSC 20/136 had reactivity to Alpha, Beta and Gamma VOC down to 7 IU/ml and for the Delta VOC to 15 IU/ml. |
Keywords : COVID-19, Variants of concern, Antibody response, Lateral flow, Vaccination, Infection
Plan
© 2021
Elsevier Ltd. Tous droits réservés.
Vol 83 - N° 4
P. e18-e20 - octobre 2021 Retour au numéro
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