Low incidence rate of diarrhoea in COVID-19 patients is due to integrin - 21/09/21
Doi : 10.1016/j.jinf.2021.07.007
Shan Gao a, b, c, 1, Yue Lu a, b, c, 1, Junwen Luan a, b, c, Leiliang Zhang a, b, c, ⁎ 
a Department of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China
b School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
c Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
⁎Corresponding author at: Department of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.Department of Laboratory MedicineThe First Affiliated Hospital of Shandong First Medical UniversityJinanShandongChina
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Highlights |
• | SARS-CoV-2 S associates with integrin β5 and integrin αV. |
• | ACE2 interacts with integrin β5 and integrin αV. |
• | Integrin could interfere with the binding of ACE2 and SARS-CoV-2 S. |
• | Integrin inhibits SARS-CoV-2 entry. |
• | Expression levels of intestinal integrin are high. |
Mots-clés : COVID-19, SARS–CoV-2, Integrin, Diarrhoea
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© 2021
Elsevier Ltd. Tous droits réservés.
Vol 83 - N° 4
P. 496-522 - octobre 2021 Retour au numéro
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